Do not use both sodium nitrite and methylene blue The recommended dose rate in acute cyanide poisoning in dogs is 79 mg/kgġ0–20 mg/kg sodium nitrite administered IV as 20% solution, up to 600 mg/kg of sodium thiosulfate as 20% solution This is sufficient to bind 100 mg of cyanide. Hydroxocobalamin: Human dose is one 2.5 g ampoule with 100 mL of 0.9% saline, administered IV over 15 min, followed by a second ampoule in the same volume over the same time. Treatment may be repeated at half the initial doses after 30 min Sodium nitrite IV, 16–22 mg/kg, as a 3% solution followed by IV sodium thiosulfate, 1.65 mL of a 25% solution. Sodium thiosulfate may be used alone in mild toxicosis Sodium nitrite followed by sodium thiosulfate Pamidronate sodium: slow (2–4 h) intravenous infusion in saline, at 1.3–2 mg pamidronate sodium/kg BWĪmmonium tetrathiomolybdate, 1.7–3.4 mg/day IV or SC, for three treatments on alternate daysĭ-Penicillamine, 50 mg/kg orally for up to 6 days Pamidronate sodium (or other bisphosphonate as available) Oxygen (pure or with not more than 5% CO 2) Remainder is administered IM or SC if a response is seen to the IV bolus Give 1/4 of dose immediately, IV if possible. IV calcium gluconate or calcium chloride, 10% solution in salineĪtropine 0.25 to 0.5 mg/kg BW. Succimer: 10 mg/kg PO, three times daily for 10 daysĭimercaprol: 3–6 mg/kg IM, 3 to 4 times daily, or 2–5 mg/kg IM every 4 h for 2 days, then every 8 h for 1 day, and every 12 h thereafter Horses: as for ruminants but do not exceedĭimercaptosuccinic acid (succimer), 2-3-dimercapto-1-propanesulfonate, or meso-2,3-dimercaptosuccinic acid Ruminants: 0.5–1.5 mg/kg phytonadione SC or IM, not more than 10 mL/site Small animals: 3–5 mg/kg/day PO, split into two doses/day, and followed by a fatty meal if possible Intravenous injection of yohimbine at 0.1 mg/kg BWĪnticholinergic drugs (atropine, hyoscamine, scopolamine, etc.) Intravenous injection of 0.2 mg atipamezole/kg BW
Dogs: intramuscular injection of 50 µg atipamezole/kg bodyweight (BW)
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